Paper Title:
Effect of Size on Degradation of Porous Poly(Lactic Acid) Scaffold
  Abstract

Poly (lactic acid) (PLA) scaffolds with different sizes are often fabricated for various requirements. A cellular automaton simulation was used to investigate the effect of the size on the degradation behaviors of porous PLA scaffolds. Four porous PLA scaffolds with 90% initial porosity and different sizes were established by a novel repeat unit method. Mass loss and the change in molecular weight during the degradation were simulated. The results indicate that mass loss is related to the size of the porous scaffold while molecular weight change is independent on the size. With the size of the porous scaffold increasing, the mass loss increases while the difference in mass loss between the scaffolds with different sizes decreases. All these changes can be attributed to the difference in the autocatalytic effect and corresponding oligomer diffusion ability of the porous scaffolds with different sizes.

  Info
Periodical
Advanced Materials Research (Volumes 311-313)
Chapter
Biomaterials
Edited by
Zhongning Guo
Pages
1741-1745
DOI
10.4028/www.scientific.net/AMR.311-313.1741
Citation
C. Guo, X. B. Sheng, C. L. Chu, Y. S. Dong, "Effect of Size on Degradation of Porous Poly(Lactic Acid) Scaffold", Advanced Materials Research, Vols. 311-313, pp. 1741-1745, 2011
Online since
August 2011
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Price
$32.00
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