Co-electrospinning has been one of the most important and viable methods to prepare microfibers with hollow structure. In the process of co-electrospinning, microfibers were formed from polymer solution or melt by the action of high voltage electric field. In this article, the compound Taylor cone, a major parameter determining success or failure to prepare the hollow microfibers, was studied and the patterns of compound cone were summarized. The microfibers with single, double and triplicate holes in the cross-section were fabricated successfully under the guide of these patterns. The morphology of hollow microfibers was observed by scanning electron microscope (SEM).