Microstructures, mechanical and creep properties of as-cast and as-annealed Mg-4Al-2Sr-1Ca (AJX421) alloy were investigated. The as cast microstructures of the alloy consists of the α-Mg, lamellar eutectic Mg2Ca and bulky Mg-Al-Sr phase. After annealing at 400°C, lamellar eutectic tended to be spheroidised and the continuous interphase network breaks up gradually, meanwhile, C14-Mg2Ca completely transforms to C15-Al2Ca. These results in obvious decrease of creep property. It is proposed that the continuous network distribution of compounds paly a major role in restricting the creep deformation of Mg-Al alloy at elevated temperatures, and the grain boundary sliding is an important creep mechanism for the alloy studied.