Paper Title:
Preparation and Properties of the Drug-Loaded Films of Polyvinyl Alcohol-Graft-Fibroin Peptides
  Abstract

Research of biomaterials made from synthesized polymer and naturally occurring macromolecules is a promising subject. The paper reported a series of drug-loaded films manufactured by a method of solution casting, taking polyvinyl alcohol-graft-fibroin peptides (PVA-g-FP) obtained by a graft copolymerization of PVA with allyl fibroin peptides (AFP) as the polymer matrix and, the ornidazole as the model drug. The mechanical property, moisture content, dissolution degree,water absorption and water-vapor transmission rate of the films were determined respectively, and the crystalline of the films were characterized via X-ray diffraction, the morphology of the films and the dispersity profile of the drug ornidazole loaded in the matrix of PVA-g-FP were investigated via the scanning electronic microscopy (SEM). It was concluded that: with the increase of the graft efficiency of FP in the PVA-g-FP films, the mechanical property and the degree of crystalline reduced gradually; but the moisture content, dissolution degree and water-vapor transmission rate rised gradually, and especially, the dispersity of the drug loaded in the PVA-g-FP matrix improved evidently. The results may be useful in exploiting biomaterials such as artificial skin, drug delivery systems and wound dressings.

  Info
Periodical
Chapter
Chapter 1: Key Engineering Materials
Edited by
Jun Hu and Qi Luo
Pages
202-209
DOI
10.4028/www.scientific.net/AMR.320.202
Citation
Q. Wang, L. Qi, "Preparation and Properties of the Drug-Loaded Films of Polyvinyl Alcohol-Graft-Fibroin Peptides", Advanced Materials Research, Vol. 320, pp. 202-209, 2011
Online since
August 2011
Authors
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Bum Rae Cho
Abstract:Indium tin oxide (ITO) used in many applications such as electronic and optical devices were deposited on the soda lime glass substrate by...
195
Authors: Xiu Rong Zhuo, Xue Gang Luo, Xiao Yan Lin, Yan Chen, Chang Gang Xu
Abstract:TiO2 / KGM composite membranes were prepared by blend. Effects of the content of TiO2 and glycerol, ratio of PVA to KGM on tensile strength...
353
Authors: Bajirao K. Sonawane, Mukesh P. Bhole, Dnyaneshwar S. Patil
Abstract:Single crystalline a-axis Mg doped ZnO thin films (MgxZn1-xO) were successfully prepared by sol-gel spin coating method using Zinc acetate,...
2915
Authors: Ping Luan, Jian Sheng Xie, Jin Hua Li
Chapter 3: Surface, Subsurface, and Interface Phenomena
Abstract:Using magnetron sputtering technology, the CuInSi thin films were prepared by multilayer synthesized method. The structure of CuInSi films...
822
Authors: Qi Ping Zhang, Qing Qing Fang, Wei Na Wang, Qing Rong Lv, Yan Mei Liu, Han Ming Zhang
Chapter 14: Thin Films
Abstract:In this paper, we investigated the structure of SmCo films with different thickness and the effects of Cr buffer layer on the structure and...
2415