To investigate the effect of incorporating traditional manufacturing factors into Multidisciplinary Design Optimization (MDO) process, cost-profit model was established and Collaborative Optimization (CO) was adopted to optimize the objective taking account of the traditional manufacture discipline as well as other disciplines. At the same time, the model without a manufacture discipline was also calculated using CO strategy for the purpose of comparison here. The multidisciplinary method was instantiated by a typical flight vehicle design problem. Results of simulation and sensitivity analysis show that the total profit of design is increased as compared to former design without involving manufacture discipline, and more control flexibility is obtained. Hence it stands to reason to conclude that manufacture should be treated as a discipline in typical MDO processes in further study.