Paper Title:
Toxicological Impact of Air Pollution Particulate Matter (PM2.5) Collected under Urban, Industrial or Rural Influence: Occurrence of Oxidative Stress and Inflammatory Reaction in BEAS-2B Human Bronchial Epithelial Cells (Corrected Version)
  Abstract

Exposure to air pollution Particulate Matter (PM) is one of the risk factors involved in the high incidence of respiratory and cardio-vascular diseases. In this work, to integrate inter-seasonal and inter-site variations, fine particle (PM2.5) samples have been collected in spring-summer 2008) and autumn 2008-winter 2009, in Dunkerque (France) under urban or industrial influence, and in Rubrouck (France), under rural influence. Attention was paid to characterize their physico-chemical characteristics, and to determine their ability to induce oxidative stress and inflammatory response in a human bronchial epithelial cell model (BEAS-2B cell line). Physico-chemical characterization of the six PM samples showed their heterogeneities and complexities depending upon their respective natural and/or anthropogenic emission sources. Lung cytotoxicity of these air pollution PM2.5 samples, as shown in BEAS-2B cells, might rely on the induction of oxidative stress conditions and particularly on the excessive inflammatory response.

  Info
Periodical
Chapter
Chapter III: Applications
Edited by
Maher Soueidan, Mohamad Roumié and Pierre Masri
Pages
489-492
DOI
10.4028/www.scientific.net/AMR.324.489
Citation
M. Dergham, S. Billet, A. Verdin, D. Courcot, F. Cazier, P. Shirali, G. Garçon, "Toxicological Impact of Air Pollution Particulate Matter (PM2.5) Collected under Urban, Industrial or Rural Influence: Occurrence of Oxidative Stress and Inflammatory Reaction in BEAS-2B Human Bronchial Epithelial Cells (Corrected Version)", Advanced Materials Research, Vol. 324, pp. 489-492, 2011
Online since
August 2011
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Price
$32.00
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