Generally in the grinding of modern aviation materials such as nickel-based superalloys, problems frequently occur in terms of burr formation, profile loss of the wheel, high heat generation in the contact zone, high grinding forces as well as low process reliability. A recent and promising method to overcome these technological constraints is the use of ultrasonic assistance, where high-frequency and low amplitude vibrations are superimposed on the movement of the workpiece. This paper presents the design of an ultrasonically vibrated block sonotrode and the experimental investigation of ultrasonically assisted profile grinding of Inconel 718. The profile wear, radial wear of the wheel, grinding forces and surface roughness by ultrasonic-assisted and conventional profile grinding were measured and compared. The obtained results show that the application of ultrasonic vibration can decrease the radial wear of the wheel, profile wear, grinding forces and surface roughness considerably.