Precise dynamic model of spacecraft is essential for the space missions, to be completed successfully. Nevertheless, the independent orbit or attitude dynamic models can not meet high precision tasks. This paper developed a 6-DOF relative coupling dynamic model based upon the nonlinear relative motion dynamics equations and attitude kinematics equations described by MRP. Nonlinear synchronization control law was designed for the coupled nonlinear dynamic model, whose close-loop system was proved to be global asymptotic stable by Lyapunov direct method. Finallly, the simulation results illustrate that the nonlinear adaptive synchronization control algorithm can robustly drive the orbit and attitude errors to converge to zero.