Computational simulations are used for the optimization of production processes in order to significantly reduce the need for costly experimental optimization approaches. Yet individual simulations can rarely describe more than a single production step. Hence, a set of simulations has to be used to simulate a contiguous representation of a complete production process. Besides, simulated results have to be analyzed by domain experts to gather insight from the performed computations. In this paper, an IT-infrastructure is proposed that aims at a rather non-intrusive way of interconnecting simulations and domain expert’s knowledge to facilitate the collaborative setup, execution and analysis of distributed simulation chains.