Taken the roof of Shenzhen citizen center with huge size and very complicated structure as the engineering background, the intelligent methods of safety monitoring of integer behavior for large span complex space truss structures under wind-excited by the data-acquisition based on limited sensors are discussed in detail in this paper. In order to acquire the working status of the whole structure, the method that can be adopted to obtain structural real-time response under wind load is listed as follows, step1: to identify the wind load; step 2: to update the structural finite element model; step 3: to measure peak factor of structural response; step 4: to directly analyze the structural real timely response. The first two steps are key techniques among all the steps of the method. The weighted proper orthogonal decomposition technique is adopted to identify the characteristics of wind pressures at all internal nodes on the truss structural roof in the frequency domain by using the measured wind pressure data from non-uniformly taps. Moreover, by using measured structural acceleration response from finite acceleration sensors on the structure, the accurate analytical model of the structure is established by updating the finite element model based on modifying node parameters. Then, the monitoring result of entire truss structure in the worst working performance in every ten minutes is obtained according to positive deductive method with the measured mean wind speed and wind direction from anemometer and peak factor acquired from finite strain gauges on the truss structure in every 10 minutes. Finally, based on the above-mentioned method, working status intelligent monitoring system is established, which can display the stress level and safe class of all structural members.