At long standoff, a shaped charge with small cone angle will produce a jet with a high tip velocity and a low tail velocity, causing it to stretch and break up, so its penetration ability into multilayer metal targets is very weak, while the penetration depth of explosively formed projectiles is too low to penetrate into multilayer metal targets. On account of this, the large cone angle shaped charge, whose internal cone angle is about 100 degree, is proposed and designed in the paper. The sensitivity of penetration effect into targets to the cone angle of the liner is investigated by experiment. The results reveal that the shaped charge penetration into multilayer metal targets with large interval is more optimistic than that of the shaped charge with small cone angle and explosively formed projectiles. In numerical simulation, based on interface tracking algorithm known as markers on cell line to reconstruct material interfaces, jet penetration into metal targets is simulated in a two-dimensional multi-material Eulerian code. The numerical results are in good agreement with the experimental ones and also indicate the interface tracking algorithm has much better resolution for moving interfaces, especially effective for large deformation.