Accelerated thermal-oxidative aging tests on Nylon 66 automotive airbag material are designed and performed in this paper. After the environmental profile of airbag was analyzed, Nylon 66 airbag yarns were reasonably selected as the test samples, and its tensile strength was chosen as the significant character of their aging stability. By heat aging、humidity aging、cycle ageing and comprehensive process aging experiments, 350dtex Nylon 66 filament were sampled and the tensile strength loss of samples was measured, to determine the mechanisms and factors that influence aging stability of the Nylon 66 airbag materials. The experiment results show that Nylon 66 has excellent aging stability, and that water molecules can accelerate its degradation. The experiment data can be used to predict the airbag lifetime in a benign store environment, and as references in selecting airbag materials.