Paper Title:

Study on the Disaggregation of Photosensitizer Pentalysine β-Carbonyl-Phthalocyanine Zinc In Vitro

Periodical Advanced Materials Research (Volumes 335 - 336)
Main Theme Advanced Materials and Structures
Edited by Yun-Hae Kim, Prasad Yarlagadda, Xiaodong Zhang and Zhijiu Ai
Pages 363-367
DOI 10.4028/www.scientific.net/AMR.335-336.363
Citation Chun Yan Li et al., 2011, Advanced Materials Research, 335-336, 363
Online since September, 2011
Authors Chun Yan Li, Guan Yu Ruan, Sheng Xiong Dong, Xiao Li Shi, Jin Can Chen, Ming Dong Huang
Keywords Disaggregation, Human Serum Albumin, Modeling, Phthalocyanine Zinc, Spectroscopy
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Abstract

A novel photosensitizer, pentalysine β-carbonyl-phthalocyanine zinc [ZnPc-(Lys)5] has tendency to form aggregate in aqueous solution. The observed in vivo Photodynamic therapy (PDT) effect of ZnPc-(Lys)5 suggests a disaggregation mechanism. In this study, the equilibrium binding constant Ka, the numbers of binding sites n and the distance of Forster radii r between ZnPc-(Lys)5 and human serum albumin (HSA) are measured by Spectroscopy. A molecular model of HSA-ZnPc-(Lys)5 complex was generated according to these datum. This molecular model provides rationale that the molecular interaction between HSA and ZnPc-(Lys)5 facilitates the dissociation of ZnPc aggregates.