Study on the Disaggregation of Photosensitizer Pentalysine β-Carbonyl-Phthalocyanine Zinc In Vitro
| Periodical | Advanced Materials Research (Volumes 335 - 336) |
|---|---|
| Main Theme | Advanced Materials and Structures |
| Edited by | Yun-Hae Kim, Prasad Yarlagadda, Xiaodong Zhang and Zhijiu Ai |
| Pages | 363-367 |
| DOI | 10.4028/www.scientific.net/AMR.335-336.363 |
| Citation | Chun Yan Li et al., 2011, Advanced Materials Research, 335-336, 363 |
| Online since | September, 2011 |
| Authors | Chun Yan Li, Guan Yu Ruan, Sheng Xiong Dong, Xiao Li Shi, Jin Can Chen, Ming Dong Huang |
| Keywords | Disaggregation, Human Serum Albumin, Modeling, Phthalocyanine Zinc, Spectroscopy |
| Price | US$ 28,- |
A novel photosensitizer, pentalysine β-carbonyl-phthalocyanine zinc [ZnPc-(Lys)5] has tendency to form aggregate in aqueous solution. The observed in vivo Photodynamic therapy (PDT) effect of ZnPc-(Lys)5 suggests a disaggregation mechanism. In this study, the equilibrium binding constant Ka, the numbers of binding sites n and the distance of Forster radii r between ZnPc-(Lys)5 and human serum albumin (HSA) are measured by Spectroscopy. A molecular model of HSA-ZnPc-(Lys)5 complex was generated according to these datum. This molecular model provides rationale that the molecular interaction between HSA and ZnPc-(Lys)5 facilitates the dissociation of ZnPc aggregates.