There are different modes of damage in any engineering structures, and most of them are cracks. In order to study the influence of coupling effect on the fatigue life, a calculation method of structure vibration fatigue life with crack propagation is proposed. In analysis, a series of finite element model with crack of different length is built to simulate the crack propagation, and Paris equation is employed to calculate the vibration fatigue life by stepwise method. The crack initiation life is got based on the change law of natural frequency from test results, and the total life is calculated in the end. Results indicate that the simulation results identical with the experimental results well.