In this study we use the CAE technology to compute and reduce the radiated noise of range hood. First, a finite element model of a typical range hood is created using Hypermesh. Then, the surface particle velocity is carried out in Nastran, and the radiated noise is calculated by Sysnoise. Finally, the DOE-based structural optimization is preformed using iSIGHT-FD, in which the sound pressure level at four sensitive points and the radiated sound power are selected as the objective function and the thickness of four panels are adopted as design variable. In addition, the weight of the range hood as a constraint is kept no more than its original weight. As a result, a maximum radiated sound power reduction of 3.66W and a maximum sound pressure level reduction of 4.7 dB are successfully achieved. It shows the CAE technology is a very efficient and effective method for reducing radiated noise.