Paper Title:
Mutagenesis, Screening and Industrialization of High Avermectin B1a Producing Strains from Streptomyces Avermitilis Irradiated by 12C 6+ Ion Beam
  Abstract

Heavy ion irradiation induced mutation is a unique method of physical mutation, with various parameters, high LET and RBE characteristic. The spore suspension of streptomyces avermitilis were irradiated by carbon ions with doses of 0、30、40、50、60 and 70 Gy. The high avermectin producing strain was successfully obtained after the mutagenesis processing by heavy ion beam and the screening of orthomutation strains. Two strains(No.203 and No.148) which potency was 5200μg/ml was sieved and its potency increased 38.64% than the original strain. The obtained strains were used for 1 ton fermentation tank and the pilot 5-ton fermentation tank amplification tests.

  Info
Periodical
Chapter
Chapter 7: Other Related Topics
Edited by
Zhijiu Ai, Xiaodong Zhang, Yun-Hae Kim and Prasad Yarlagadda
Pages
652-655
DOI
10.4028/www.scientific.net/AMR.339.652
Citation
S. Y. Wang, J. H. Chen, W. J. Li, J. P. Liang, Y. H. Bo, X. Q. Ma, J. Liu, "Mutagenesis, Screening and Industrialization of High Avermectin B1a Producing Strains from Streptomyces Avermitilis Irradiated by 12C 6+ Ion Beam", Advanced Materials Research, Vol. 339, pp. 652-655, 2011
Online since
September 2011
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Price
$32.00
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