To obtain detailed micron-scaled pore size distribution for cotton-polyester fabric (CPF), this study focus on the influence of wicking liquid properties on size distribution with three kinds of wicking liquid. For three kinds of wicking liquid, the paper reveal that it is difficult to fully characterize the specific pore size distribution with only one wicking liquid. The results illustrate that the surface tension has a significant impact on the pore size distribution as well as mean pore size. It is found that the whole graphics shift towards the large pore size direction and even result in the disappearance of smaller pore size with decreasing the surface tension and with increasing viscosity. The emergence of larger pore size, instead of smaller one, may be due to the wetting expansion by larger viscosity liquid. Meanwhile, it is obvious that the pore in peak area become dominant, accounting for more than 75%.