Paper Title:
Development of a Novel CaP-Containing Mesoporous Silica-Based Xerogels Used as Hemostatic Material with Good Biodegradability and Low Heat Generation
  Abstract

A novel Ca/P-containing mesoporous silica-based xerogels (CaMSX) with good degradability and low heat generation were synthesized for hemorrhage control by a modified sol-gel process and physicochemically characterized. The mesoporous silica-based xerogels without Ca/P (MSX) was also prepared as comparison. The in vitro whole blood coagulation time, activated partial thromboplastin time (APTT) and prothrombin time (PT) of the CaMSX were measured with MSX, Chinese traditional medicin-Yunnan medical powder (YM) and traditional zeolite. In vivo bleeding model was tested with rabbit’ ear side veins. The results illustrated that the CaMSX could remarkably promote the intrinsic and extrinsic blood coagulation processes which greatly depend on the dosage and the content of Ca in the CaMSX. The CaMSX had better efficiency in promoting coagulation process than that of MSX, YM and zeolite.

  Info
Periodical
Chapter
Session 2: Biomaterial Science
Edited by
Honghua Tan
Pages
222-228
DOI
10.4028/www.scientific.net/AMR.340.222
Citation
X. S. Li, W. Lin, F. L. Xin, Y. Yuan, C. S. Liu, C. L. Da, "Development of a Novel CaP-Containing Mesoporous Silica-Based Xerogels Used as Hemostatic Material with Good Biodegradability and Low Heat Generation", Advanced Materials Research, Vol. 340, pp. 222-228, 2012
Online since
September 2011
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