Paper Title:
Bioinformatics Analysis of Zinc-Alpha2-Glycoprotein,a Potential Serological Marker for Hepatocellualr Carcinoma
  Abstract

To Analyze the structure and function of Zinc-alpha-2-glycoprotein (ZAG), a highly expressed serum protein in the patients with hepatocellular carcinoma (HCC). The serum proteome of the patients from HCC, liver cirrhosis and healthy donors were separated and identified by two-dimensional electrophoresis and MALDI-TOF-MS. RT-PCR and Western blotting analysis were used to confirm ZAG highly expressed in HCC. Bioinformatics technologies were used to analyze the structure character of ZAG protein. Five differentially expressed proteins were identified. Albumin, Serotransferrin,CD5 antigen-like precursor ( IgM - associated peptide) were down-regulated in HCC, ZAG and Ig gamma-1 chain C region were up-regulated in HCC. Zinc-alpha-2-glycoprotein (ZAG), a lipid mobilizing factor, is a member of the major histocompatibility complex (MHC) class I family of protein. ZAG protein might be a potential serological biomarker for HCC early diagnosis.

  Info
Periodical
Chapter
Session 2: Biomaterial Science
Edited by
Honghua Tan
Pages
390-396
DOI
10.4028/www.scientific.net/AMR.340.390
Citation
F. Wang, Y. Geng, W. M. Zhang, X. Geng, "Bioinformatics Analysis of Zinc-Alpha2-Glycoprotein,a Potential Serological Marker for Hepatocellualr Carcinoma", Advanced Materials Research, Vol. 340, pp. 390-396, 2012
Online since
September 2011
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$32.00
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