Paper Title:
Proteomics Study on Cross-Linking Reaction of Formaldehyde and HSA
  Abstract

Possible clinical diagnosis biomarkers of diabetes were proposed using proteomics and bioinformatics methods through the preliminary study on the formaldehyde-human serum albumin crosslinkage. Using LC/MS techniques, the experiment on in vivo cross-linking reaction of formaldehyde with pure protein or plasma protein revealed that the cross-linking reaction of human serum albumin and forrmaldehyde would occur and the concentrations of some normal peptides would change. A group of significant peptides of human serum albumin were selected. As the results of in vivo cross-linking reaction, Non-enzymatic glycosylation modification of HSA were observed in diabetic. The same change of the concentrations of some peptides happened. The above-mentioned results were demonstrated with the hematoplasmas of normal people and diabetics.

  Info
Periodical
Advanced Materials Research (Volumes 343-344)
Chapter
Session 3: Biology-Related Materials Research in Environmental Protection
Edited by
David Wang
Pages
1035-1041
DOI
10.4028/www.scientific.net/AMR.343-344.1035
Citation
B. Li, D. Y. Hu, X. L. Xin, R. Lan, Y. L. Deng, "Proteomics Study on Cross-Linking Reaction of Formaldehyde and HSA", Advanced Materials Research, Vols. 343-344, pp. 1035-1041, 2012
Online since
September 2011
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Price
$32.00
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