Paper Title:
Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride
  Abstract

An alkaloid compound, lappaconitine Hydrochloride, was synthesized with lappaconitine which was isolated from the root of Aconitum sinomontanum Nakai in Gansu province in China. The structures were elucidated by IR, NMR, Anal. and X-ray diffraction analysis. Crystal data: C32H47ClN2O9, Mr = 639.17, space group monoclinic, P21; a=10.665 (7) Å, b=12.178 (7) Å and c=12.214 (7) Å; β=91.003 (10)°, Z=2, Dx = 1.338 mg/m-3, F(000)= 684, µ=0.18.00 mm-1, V=1586.1 (16) Å3; R1=0.038, wR2=0.087, Flack parameter x= -0.12 (7). Ring A, B, C, D, E and F respectively present boat, chair, envelope, boat, boat and envelope forms. The absolute configuration was determined as 1S, 4S, 5S, 7S, 8S, 9S, 10S, 11S, 13R, 14S, 16S, 17 R. And the analgesic potential has been investigated in a mouse model of acute pain. The result exhibited that the analgesic effect of the compound is worse than lappaconitine hydrobromide.

  Info
Periodical
Advanced Materials Research (Volumes 343-344)
Chapter
Session 3: Biology-Related Materials Research in Environmental Protection
Edited by
David Wang
Pages
1049-1052
DOI
10.4028/www.scientific.net/AMR.343-344.1049
Citation
W. X. Sun, T. G. Dong, C. M. Ding, "Crystal Structure Analysis and Antinociceptive Property of Lappaconitine Hydrochloride", Advanced Materials Research, Vols. 343-344, pp. 1049-1052, 2012
Online since
September 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Xue Tao Xu, Kun Zhang, Zhi Yun Du, Yu Jing Lu, Rui Rui Zhang, Hua Zhu
Abstract:Five phenolic hydroxyl-substituted distyryl ketones had been synthesized, characterized and evaluated as pH-dependent fluorescent probes for...
1143
Authors: Wen Xiu Sun, Ai Ai Yuan, Cai Yan Zhang, Tun Galag Dong
Abstract:C32H45N2O8Cl2Cu Monoclinic, P2/1, a = 10.665(2)Å, b = 12.4197(2)Å, c = 12.1995(3)Å,...
2242
Authors: Zhan Wan Shi, Ying Wang, Xing Dong Yao
Chapter 11: Environmental Protection and Economic Development
Abstract:a new rosin derivative—methylthiomethyl dehydroabietate has been synthesized from dehydroabietic acid and DMSO. The effects of reaction...
1694
Authors: Run Tao Dong, Qing Bin Xue, Ling Min Sun, Quan Xuan Zhang
II. Chemistry of Liquid Crystals
Abstract:A series of azobenzene containing group Poly (L-lactic acid) (PLLA) were synthesized by Ring-Opening Polymerization of L-lactide (L-LA)...
185
Authors: Ying Jie Cai, Xiu Jie Ji, Bo Wen Cheng, Dong Dong Xie, Qiu Ling Wang, Jun Song, Yuan Lin Ren, Xian Lin Xu, Guo Feng Zhang, Bo Wei Li, Zhi Xiong Yang
Chapter 1: Academic Frontiers
Abstract:The title compound (C7H9ClN2, Mr = 156.61), an imidazolium ionic liquid with alkynyl, was synthesized by an...
173