The performance of thiacalixarenetetrasulfonate (TCAS) for the treatment of soils contaminated with lead was evaluated in this study. Batch experiments were performed to test the factors influencing remediation of lead-polluted soil. The effects of temperature, solid-liquid ratio and the ionic strength on the removal capacities of lead by TCAS reagent had been studied. The results showed that the TCAS reagent was effective for removal of lead from the contaminated soil, the optimum temperature of TCAS for soil treatment was 5°C-25°C. The optimum solid-liquid ratio was 1:10 for soil treatment. Adding Ca(NO3)2 was of no advantage for lead removal, and the effect of Ca(NO3)2 on the removl rate was less when its molarity was less than 0.01mol/L. This experimental work has also demonstrated the great importance of soil matrix for the evaluation of the TCAS leaching as a cost effective remedial option.