Based on the semi-static two compartment model, the bioconcentration and elimination of copper with tissues of Styela clava were investigated. The kinetic parameters (accumulation rate constant k1, elimination rate constant k2, bioconcentration factor BCF, biological half life t1/2 and maximum equilibrium concentration CAmax) were obtained by non-linear regression. The results showed S. clava could accumulate copper from the aquatic environment and that BCF decreased with increasing metal concentration in water. When the accumulation achieved balance, CAmax showed positive correlation to metal concentrations in water. Concentrations of copper in different tissues of S. clava were in the order of gonad > digestive gland ≈ other part >tunic, and t1/2 of copper was 12.57 to 38.18 days in elimination phase. The high rate to accumulate and eliminate copper from its body exhibited a useful potential biomonitor of short-term copper fluctuations status in marine system.