Paper Title:
Impacts of Sodium Citrate on Metabolic Flux Distributions of L-Valine Fermentation
  Abstract

The effect of sodium citrate on the metabolic flux distributions in the middle and late periods of L-valine production by Corynebacterium glutamicum XV0505 was obtained. It was shown that when sodium citrate (2.0 g/L) was added into the initial fermentation culture medium, the metabolic flux of Embden-Meyerhof-Parnas (EMP) route decreased from 96.43 to 91.13, and the metabolic flux of Hexose Monophophate (HMP) route increased from 3.56 to 8.87, and the metabolic flux flowing to L-alanine and acetate was decreased by 21.1% and 32.4%, respectively. Meanwhile, the metabolic flux of biosynthesis route of L-valine was increased by 10.74%. Therefore, sodium citrate can change the metabolic flux distribution in the key nodes of biosynthesis route of L-valine, decrease the generation of byproducts, and increase the metabolic flux in the biosynthesis route of L-valine.

  Info
Periodical
Advanced Materials Research (Volumes 343-344)
Chapter
Session 2: Materials for Biomedical Engineering Application
Edited by
David Wang
Pages
643-648
DOI
10.4028/www.scientific.net/AMR.343-344.643
Citation
Q. Y. Xu, L. Ma, X. X. Xie, N. Chen, J. Wang, "Impacts of Sodium Citrate on Metabolic Flux Distributions of L-Valine Fermentation", Advanced Materials Research, Vols. 343-344, pp. 643-648, 2012
Online since
September 2011
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Price
$32.00
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