To investigate the characters of Sorangium strains and the approaches for improving the production of epothilone, correlation of epothilone production and morphogenesis was studied in strains So0157-2, So0007-3 and So0003-3. On lean medium, So0157-2 could produce epothilones in a wide pH range (5.0-12.0), but formed fruiting bodies at high pH values (9.0-14.0). Formation of fruiting body did not affect the yield of epothilones in So0157-2. In So0007-3 and So0003-3, producing of epothilone was strongly coupled with the process of morphogenesis. It suggests that reduction of the association between morphogenesis and epothilone producing would prominently improve the epothilone production.