The Signal Pathways of Immune Inflammation Mediated by the Tlr3/Nf-Kappab and Activator Protein-1 in Cells Infected with Influenza A Virus Antagonized by Baicalin
| Periodical | Advanced Materials Research (Volume 345) |
|---|---|
| Main Theme | Smart Materials and Nanotechnology in Engineering |
| Edited by | J.L. Zhong |
| Pages | 201-209 |
| DOI | 10.4028/www.scientific.net/AMR.345.201 |
| Citation | Chun Jing Zhang et al., 2011, Advanced Materials Research, 345, 201 |
| Online since | September, 2011 |
| Authors | Chun Jing Zhang, Hai Tao Yu |
| Keywords | Activating Protein-1, Baicalin, Immune and Inflammatory Cytokines, Influenza A Virus, Nuclear Factor-Kappa B, Toll-Like Receptor 3 |
| Price | US$ 28,- |
Baicalin has better anti-inflammatory function, antioxidant function and antiviral activity, but the mechanism of the antiinfluenza viral activity of baicalin has not been revealed.Toll-like Receptor 3 and the signal pathways mediated by TLR3 were affected and controlled by the infections with influenza A virus. We report here the significant activity and part mechanism of baicalin against H3N2 influenza A viruses. Baicalin could well protect the damages of cells caused by influenza A virus, it also could effectively inhibit the production of CPE in cells caused by influenza A virus and the inhibition of cells growth. The mechanism of antiinfluenza virus infection of baicalin may be related with the following aspects: to decrease the transcriptional activity of the oxidative stress sensitive transcription factor NF-kappaB and AP-1 by moderately decrease the higher expression level of TLR3 mRNA and the higher expression level of protein; and to further inhibit the mRNA expression of the downstream target genes IL-1β, IL-8, RANTES and IFN-β thereby alleviate the inflammatory injuries and restore the stability and balance of immune function in vivro.
