Paper Title:
[D-Ala2, D-Leu5]-Enkephalin (Dadle) Reduces Inflammation Responses after Transient Global Ischemia
  Abstract

[D-Ala2, D-Leu5]-Enkephalin (DADLE) is a δ-opioid receptor antagonist and has been shown to reduce neuronal loss in the selectively vulnerable brain regions after transient global ischemia. Here, we investigate whether this protection is mediated by the DADLE's modulation of the postischemia inflammation responses. After implanted with cannula at the right lateral ventricle, rats underwent 10 minutes of transient global ischemia by four vessel occlusion. Rats received a single infusion of DADLE (12.5 nmol) via the intracerebral cannula at the onset of reperfusion. At the time of 72 h after ischemia, we investigated GFAP expression via immunohistochemistry. we also tested the level of MDA and the activities of SOD and CAT. The results show that DADLE can reduce reactive astrocytosis and increase SOD activities. The study reveals the neuroprotection mechanism of DADLE in the ischemic brain is related to reduce inflammation responses.

  Info
Periodical
Chapter
Chapter 2: Smart Materials for Biomedical Engineering Application
Edited by
J.L. Zhong
Pages
343-348
DOI
10.4028/www.scientific.net/AMR.345.343
Citation
S. Y. Wang, Y. L. Duan, Q. W. Zeng, Z. Zhao, X. R. Wang, "[D-Ala2, D-Leu5]-Enkephalin (Dadle) Reduces Inflammation Responses after Transient Global Ischemia", Advanced Materials Research, Vol. 345, pp. 343-348, 2012
Online since
September 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Lin Liu
Chapter 8: Waste Disposal and Recycling
Abstract:Pesticides play an important role in development of agricultural in China. Pesticides play a significant role in the effective control of...
3175
Authors: Xue Mei Han, Hong Tao Wei, Song Yan Liu
Chapter 10: Chemical Biology and Medicinal Chemistry
Abstract:Abstract Objective To investigate the expression of erythropoietin (EPO) after acupuncture preconditioning plus focal cerebral ischemia...
1650
Authors: Qiu Zhen Zhao, Hua Liu, Hua Guang Li
Chapter 3: Biochemical, Medicine Engineering and Technologies, Applications of Genetic Engineering
Abstract:AIMS: To explore gene expressions of Bax and changes of cytC releasing in the CIR hippocampus neuron; to observe the effect on CIR with...
824
Authors: Peng Wan, Cheng Xi Wei, Jian Long Wu, Qing Hua Jin
Chapter 2: Environmental Chemistry and Technology
Abstract:Edible salt (ES) is also thought to exacerbate the symptoms of Alzheimer, however, the in vivo function of ES remains poorly understand. In...
326