Effective reuse and integration of multidiscipline model resources is a key issue and challenge in the Virtual Prototyping for Complex Products. Based on the Meta Object Facility and Component-based Modeling, This paper proposes a new component-based Meta Modeling Framework (M2F) of Complex Product Virtual Prototyping as a solution, providing the model specifications for each abstract layer (CAP model, CIM model and High-level model) in the framework. M2F enables multi-layered abstraction of those isomerism models in Complex Product Virtual Prototype and facilitates the unified modeling, reuse and integration of models. A case study about typical complex product indicates this approach not only makes the system-level modeling of virtual prototype easy, but also improves the reusability of component models. At the end of this paper, conclusion and future works are given.