The airlift contact oxidation process is the combination of airlift technology with contact oxidation method. The process was used to treat domestic wastewater, the appropriate operating parameters were determined by experiment, and the operation stability, anti-impact loads and treatment cost of the process were also analyzed. The results show that this process has some advantages of compact layout, small occupancy area and low treatment cost. Under the conditions of air/water ratio of 16.8 and the hydraulic loading of 4.8m3/(m3•d), the average removal rate of COD and NH3-N reaches 80.1% and 58%, respectively. The effluent quality is stable and excellent, and it can be used as municipal miscellaneous water. The height of the media can be reduced due to its internal recycling system.