Solid oxide fuel cell (SOFC) is one of most promising types of fuel cells with advantages of high efficiencies, flexibility of usable fuel types. The performance of SOFC is strongly affected by cell overall parameters, e.g., temperature, pressure, reaction rates, etc. But it is very difficult to validate internal parameters distributions and complex physical processes by experimental method. The CFD model simulation has been proved an effective method for SOFC research. In this work, a 3D CFD model is developed to simulate the working processes in SOFC’s anode. The objective of this work is to study the effects of the parameters such as temperature, permeability, pores radius and elementary surface reaction rate on the working processes, by coupling the transport processes such as mass, momentum and thermal energy with the chemical reactions of gas- and surface-phase species based on catalyst surface coverage.