Climate change and global warming issues have thrown new challenges for the economic development. Carbon dioxide emissions (CO2) are on the global agenda with regard to the climate change. This trend has led to renewed strategies in many sectors. The paper shifts the perspective of life-cycle assessment (LCA) in terms of the CO2 emission from the conventional entire product life cycle emphasis to the manufacturing processes. Based on hybrid analysis an approach to the emission calculation in manufacturing phase is developed. This approach helps the industry companies identify the emission reduction potentials in manufacturing, by focusing on the resource and energy flows and the emission intensities in manufacturing processes, therefore contributes to the LCA.