Paper Title:
Extracts of Paris Polyphylla Smith Mitigates Oxidative Stress in Human Umbilical Vein Endothelial Cells Induced by Oxidized Low Density Lipoprotein
  Abstract

Paris Polyphylla Smith is widely used in traditional Chinese medicine. For its effective of antipyretic detoxicate, its active component is steroid saponin [1]. The present study was designed to evaluate the antioxidative effect of extracts of Paris Polyphylla Smith (PPSE) and its capacity to protect human umbilical vein endothelial cells (HUVECs) against oxidative damage induced by oxidized low density lipoprotein (ox-LDL). Cytotoxicity was determined by MTT assay. Flow cytometer (FCM) demonstrated that the increased apoptosis induced by oxidized low density were inhibited, and the blocked transition of cells from static phase (G0/G1) to DNA synthesis (S) were restored by PPSE, these effect were all in a dose-dependent manner. The actions by PPSE to reduce apoptosis may help protect endothelial function and inhibit atherogenesis, while the novel actions to mitigates oxidative stress may weaken the ability of endothelial injury. Further studies are needed to identify the chemical compounds responsible in order to develop its clinical application.

  Info
Periodical
Chapter
Chapter 2: Future Materials Technology and Biomedicine
Edited by
Barry Tan
Pages
348-353
DOI
10.4028/www.scientific.net/AMR.365.348
Citation
L. L. Gao, F. R. Li, Y. H. Si, S. C. Qin, "Extracts of Paris Polyphylla Smith Mitigates Oxidative Stress in Human Umbilical Vein Endothelial Cells Induced by Oxidized Low Density Lipoprotein", Advanced Materials Research, Vol. 365, pp. 348-353, 2012
Online since
October 2011
Export
Price
$32.00
Share

In order to see related information, you need to Login.

In order to see related information, you need to Login.

Authors: Ya Kun Ge, Xiao Xiang Zheng
Session 3: Biology-Related Materials Research in Environmental Protection
Abstract:Hyperoside is a flavonol glycoside extraction from Hawthorn (Crataegus), and it has been reported that hyperoside process...
1007
Authors: Yan Shi, Chun Jing Zhang
Chapter 2: Smart Materials for Biomedical Engineering Application
Abstract:.Purposes,To explore the effects of carnosine on high glucose-induced apoptosis of human umbilical vein endothelial cells (HUVECs). Methods...
365
Authors: K.F. Xiao, J. Zhou, Zhi Wang, Wen Hui Fu, Xiang Yang Lu
Chapter 2: Smart Materials for Biomedical Engineering Application
Abstract:This paper focuses on the effect of the venom of the scorpion Heterometrus liangi on the proliferation of human KYSE-510 cell line and...
399
Authors: Shu Li Shao, Wei Wei Zhang, Wei Zhao, Guang Hui Wu
Chapter 13: Structural Materials and Biomaterials
Abstract:To observe the effects of hydroxycamptothecine(HCPT) on the growth and apoptosis of gastric cancer cell line. The viability of human leukemia...
2420
Authors: Shu Li Shao, Wen Jing Sui, Shuang Li, Wei Wei Zhang, Wei Zhao, Jin Ping Song
Chapter 1: Environmental Chemistry, Biology and Technology
Abstract:Objective To study the effect of Zedoary turmeric oil on proliferation and apoptosis of human gastric cancer cell line SGC-7901. The growth...
67