Paper Title:
Targeting Human Telomeric G-Quadruplex with Perfluoroalkyl Metal Phthalocyanine Derivatives
  Abstract

The ability of G-quadruplex ligands to induce formation of four-stranded DNA and stabilize four-stranded DNA make them able to inhibit telomerase. This paper investigated the interaction of four perfluoroalkyl phthalocyanine metal derivatives with telomeric DNA sequence 5’-d [TTAGGG)4TT-3’ by using circular dichrosim (CD), ultraviolet-visible and fluorescence spectroscopy, and molecular simulation method. Results show that perfluoroalkyl Zinic phthalocyanine can strongly induce the G-DNA in the buffer without extra K+/Na+ added with a molar ratio of 1:1 interaction possibly by intercalation into G-quartets, and only increases the amount of G-DNA in the presence of K+/Na+, with a compound/DNA 2:1 interaction possibly by external stacking model.

  Info
Periodical
Chapter
Chapter 2: Future Materials Technology and Biomedicine
Edited by
Barry Tan
Pages
382-388
DOI
10.4028/www.scientific.net/AMR.365.382
Citation
L. N. Liu, Y. L. Wu, S. K. Jiang, T. Qiu, H. F. Zhang, W. Zhang, "Targeting Human Telomeric G-Quadruplex with Perfluoroalkyl Metal Phthalocyanine Derivatives", Advanced Materials Research, Vol. 365, pp. 382-388, 2012
Online since
October 2011
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$32.00
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