Response surface methodology was used to optimize the activated carbon iodine absorption value screened by Placket-Burman design. Six effective factors such as NaOH concentrations, boiling time, liquid ratio, calcined ways, calcined time and calcined temperature were tested by using Placket-Burman design criterion and three effective factors NaOH concentrations, liquid ratio and calcined time showed significant effect(P<0.05) on iodine absorption value. By applying Box-Behnken design, the optimized condition obtained NaOH concentrations of 2.5mol/l, liquid ratio of 1/1.125 and calcined time of 37.5min. Three runs of additional confirmation experiments were conducted. The average relative error was 0.58%.