In this paper, a new shape classification method based on different feature sets using multiple classifiers is proposed. Different feature sets are derived from the shapes by using different extraction methods. The implements of feature extraction are based on two ways: Fourier descriptors and Zernike moments. Multiple classifiers comprise Normal densities based linear classifier, k-nearest neighbor classifier, Feed-Forward neural network, Radial Basis Function neural network classifier. Each classifier is trained by two feature sets respectively to form two classification results. The final classification results are a combined response of the individual classifier using six different classifier combination rules and the results were compared with those derived from multiple classifiers based on the same feature sets and individual classifier. In this study we examined the different classification tasks on Kimia dataset. For the tasks the best combination strategy was found using the product rule, giving an average recognition rate of 95.83%.