This study puts forward the framework of GIS—Scenario decision method and introduces some methods, ideas, principles and analysis process applied in regional spatial planning. Combining the GIS spatial analysis method with the scenario—planning, simulating and contrasting scenarios for regional key development zones, this study determines regional development strategies. Findings show that the GIS-SCENARIO analysis method can quantitatively analyze factors influencing the spatial distribution more accurately. Considering fully complex real situation and combined with reasonable value judgments, the GIS can provide various factors with a spatial analysis platform to contact and contrast with each other. As a strategic planning approach, it enables decision makers decide relatively reasonably in an uncertain and unpredictable situation and improves rationality in planning.