By using wavelet multi-resolution analysis, damage sensitivity in different acceleration responding signals from different locations of the structure are studied in this paper. Through numerical analysis of a five-layer frame structure, the result shows that the sensors in different location have different capabilities in denoting the damage signal. Each sensor can only denote the working status of the surrounding area. Single or some of the sensors may lead to false diagnostic results. It can be concluded that multi sensors with data fusion method is the effective way to solve the problem of limited information by single sensor.