The seismic response of curved girder bridge is more complex because of its irregular plane shape. Friction pendulum bearing (FPB) has a positive effect on structural seismic response. The seismic response mitigation effectiveness of FPB to curved girder bridge with soil-pile interaction considered is needed to research. The three-dimensional calculation model of a curved continuous girder bridge is established, and FPB are added at the positions of sliding bearings with soil-pile interaction. The influence of soil-pile interaction on seismic response mitigation effectiveness of FPB is computed and analyzed under three-dimensional ground motion action. The results show that the seismic response mitigation effectiveness of FPB is quite obvious with or without soil-pile interaction considered. Furthermore, seismic response mitigation effectiveness of FPB increases for the internal force of piers after soil-pile interaction considered. FPB has great and positive mitigation effectiveness on the seismic longitudinal displacement of the main girder of curved girder bridge, but with soil-pile interaction considered the mitigation effectiveness decreases a bit.