Based on the red clay of Wuhan reinforced by Ionic Soil Stabilizer, the red clay soil is treated by different matches of ISS at first, then is tested in the Atterberg limits test and dynamic triaxia test. The results show that the plastic index decreases, and the red clay were greatly improved under the dynamic condition, the maximum dynamic shear modulus ratio acquired an incensement of 27.72% on average after mixing the ISS into the red clay. In addition, It was concluded that the confining pressure influenced the dynamic shear modulus and damping ratio to a certain extent. Given the same strain conditions, with the incensement of confining pressure increases, the dynamic shear modulus increased and the damping ratio decreased. Moreover, when plotting the dynamic shear modulus versus the dynamic shear strain, the similar curve can be formed for both the natural soil and the modified one, the dynamic shear modulus monotonously decreased with the incensement of the dynamic shear strain. However, the value of dynamic shear modulus differed in the same shear strain between the natural soil and the soil modified by ISS.