In present work, first the multi-storeyed building was analysing taking medium site condition in zone II. Sa/g and Base shear for that building was calculated from IS 1893:2002 (Part 1).After that site specific ground response analysis is carried out for Amravati and Nagpur region soil sites. For development of site specific response spectrum ProSHAKE software is used ProSHAKE is based on one dimensional geotechnical site response model. Site response study is usually carried out using the geotechnical data or Geophysical data (shear wave velocity). Basic aim of present work is to study local site effects on seismic analysis of multi-storeyed Buildings, for this purpose local soil conditions are considered. In the present work various local sites in Amravati and Nagpur region are studied.