In order to implement the bi-level optimization strategy-collaborative optimization (CO) to bridge design, bridge optimization design process is subdivided into three subsystems in terms of component-oriented decomposition: superstructure subsystem, bearing subsystem and substructure subsystem. For system level, target function is formulated with the total direct construction cost, and inequality constraints induced relaxation factors are adopted to relax the intersubsystem consistency constraints. For subsystems, target functions are formulated with discrepancy expressions and constraints are formulated according to corresponding codes demands respectively. The feasibility and validity of the proposed approach are examined with an optimization process of reinforcement concrete box girder bridge. Optimization results from proposed approach are compared with that from mono-discipline optimization. The proposed approach shows high computing efficiency than mono-discipline optimization methods when achieving same optimization results.