As an indispensable force component to the hybrid structure, the seismic wave energy inputted into integral structure is dissipated by damping force working and plastic hysteresis of reinforced concrete shear wall which is taken as the first seismic fortification line of structure. Considering of the condition that the RC shear wall is mainly used to dissipate the seismic wave energy, this paper takes the ultimate energy dissipation capacity of reinforced concrete shear wall subjected to cyclic loading as the damage characterization. According to the related theoretical analysis and experimental research, the method for calculating ultimate energy dissipation capacity of RC shear wall is proposed and the damage sensitivity of various design parameters which contain the sectional thickness, the strength of concrete and reinforcement ratio are analyzed, then the influence laws of main design parameters impacted on damage evolution of RC shear wall are revealed in this paper. The research shows that sectional thickness is the most sensitive factor in the damage of reinforced concrete shear wall and the concrete strength degree takes the second place, and then the reinforcement ratio is the most insensitive design parameter. The research achievements will provide theoretical support for establishing the storey damage model of SRC frame-RC core wall hybrid structure under seismic excitation.