Thrust asymmetry is dangerous for aircraft, especially in the phases of approach and landing. This paper proposes a new technology to compensate the thrust asymmetry in lateral of large aircraft. The dynamic characteristics of aircraft with asymmetric thrust are firstly analyzed in the paper. Then, the controllability conditions and balanced flight attitude in the case of thrust asymmetry are studied. Based on the mathematic model of Airbus 300, a thrust asymmetry lateral compensator is designed for the phases of approach and landing to ensure the safety of approach and landing. Numerical simulation results show that the designed compensator (control law) can compensate the asymmetric thrust very well.