It is a new design and manufacturing method which forming medical image data processing technology and multi-point forming technology for titanium alloy cranial prosthesis digital design and manufacturing. First, the head of the CT data of patients according to medical image segmentation approach to the skull and scalp, brain image segmentation boundaries, using registration method to segment the skull CT image registration, and application of 3D visualization technology in patients with skull reconstruction of the mathematical model. Then on this basis, the use of thin-plate spline interpolation in accordance with the health side of the skull surface extension of the transition to be a mathematical model of the skull prosthesis. Finally, the mathematical model of the skull prosthesis passed to the multi-point forming CAD / CAM software system, so that multi-point forming the basic body to adjust the upper and lower press out the skull prosthesis forming surface, and processing the required titanium alloy cranial prosthesis. The technical solution of the skull repair system prepared in the presence of low precision machining, production costs are high, long cycle and so on, while improving the prosthesis fit and the precision of the edge defects.