Wet gas flow is a typical two-phase flow with low liquid fractions. As differential pressure signal contains rich information of flow parameters in two-phase flow metering, a new method is proposed for wet gas flow metering based on differential pressure (DP) and blind source separation (BSS) techniques. DP signals are from a couple of slotted orifices and the BSS method is based on time-frequency analysis. A good relationship between the liquid flow rate and the characteristic quantity of the separated signal is established, and a differential pressure correlation for slotted orifice is applied to calculate the gas flow rate. The calculation results are good with 90% relative errors less than ±10%. The results also show that BSS is an effective method to extract liquid flow rate from DP signals of wet gas flow, and to analysis different interactions among the total DP readings.