In this paper, a type of control system of coke machine interlocking and automatic running on PLC is proposed. The control principle, system configuration and application is introduced in detail. The design method of hardware and software on PLC is given, which is useful for the application of control system. The whole system is based on induction radio communication. It has proved that this system has the characteristics of advanced design, complete functions and high stability. It also could bring about vast economic and social benefit.