The resources on Manufacturing Grid are dynamic, diverse, distributed and isomeric, so their management is significantly complicated. However, people always want to obtain the newest resources’ information in the recent distance, in the shortest time. Thus, replica management of resource becomes necessary. This paper makes the following contributions. First, we elaborate the resources’ encapsulation technology on Manufacturing Grid. Second, we describe the main idea of replica management technology. In addition, we explain the working principle of component that is management replica—RLS (Replica Location Service). Finally, we first bring forward replica management technology of resource on Manufacturing Grid, and design a solution that resources’ replica management technology on Manufacturing Grid.