The flexural behaviour of 6-ply unidirectional hybrid fibre-reinforced polymer (FRP) matrix composites containing a mixture of E-glass and S2-glass fibres was investigated. A high performance epoxy system comprising of Kinetix® R240 epoxy resin (combined with Kinetix® H160 epoxy hardener) was utilised for the composite matrix. Flexural testing was conducted in accordance with Procedure A of the ASTM D790-03 test standard on a universal testing machine equipped with a three-point bend test rig. In addition to varying the stacking configurations of the composite prepregs, the influence of span-to-depth ratio on the flexural properties and failure mechanisms was also studied. The failure mechanisms of the resulting fractured specimens were characterised using optical microscopy and compared with those noted by the authors in previous work.