Railway vehicle structure fatigue life consumption monitoring can be used to determine fatigue damage by directly or indirectly monitoring the loads placed on critical vehicle components susceptible to failure from fatigue damage. The sample locomotive carbody structure was used for this study. Firstly, the hybrid fatigue analysis method was used with Multi-Body System (MBS) simulation and Finite Element Method (FEM) for evaluating the carbody structure dynamic stress histories. Secondly, the standard fatigue time domain method was used in fatigue analysis software FE-FATIGUE and MATLAB WAFO (Wave Analysis for Fatigue and Oceanography) tools. And carbody structure fatigue life and fatigue damage were predicted. Finally, and carbody structure dynamic stress experimental data was taken from this locomotive running between Kunming-Weishe for this analysis. The data was used to validate the simulation results based on hybrid method. The analysis results show that the hybrid method prediction error is approximately 30.7%. It also illustrates that the fatigue life and durability of the locomotive can be predicted with this hybrid method. The results of this study can be modified to be representative of the railway vehicle dynamic stress test.