Globalization has been around for a couple of centuries but never like today. Even not far just a decade ago, companies setting up a branch office overseas was a subsidiary for management team to operate. Today, there are ODM/OEM, Build-to-Order, B2B, or other kinds of business relationships, but less and less of headquarter-subsidiary relationship. The evolving of the new business relationships in today’s globalization creates a huge potential quality risk which actually exists behind the whole value chain: (1) product quality from design to manufacture, and (2) quality cost due to defective products, reputation loss, recall, delinquency, etc. The Quality System used to commit quality that serves enterprise now under pressure to reapply to a cross-the-boundary value chain environment. This paper is a case study that demonstrates a methodology solving the previously addressed quality issues by installing a Qualify System into a piecewise organization in a supply chain. In this case the quality factor has been nearly eliminated since 2000 with millions of wafers supplying from supply network by adapting this methodology: a Quality System Vee Model.